He became a Vampire and creates the first bloodline of Vampires. Eventually something happen to him. His left hand becomes the Sacred Weapon Corpse Hand and is held by the Ventrue Clan as their sacred weapon. Due to its link to Cain, it is regarded as their most sacred procession.
- Cain was the son of Adam and Eve in the Biblical Story of Genesis, who committed the first murder by killing his brother Abel.
- In Vampire: The Masquerade, Caine committed the first murder by killing his brother. When offered the chance to be forgiven for his crime by several individuals, he refused believing not he had done no wrong by sacrificing his beloved brother in the name of God, that the only one who could forgive him was himself. However, in the process of rejecting the forgiveness of others, he was cursed by God to become the first Vampire. He embraces the second generation of Vampires, of which there were 3. In turn, they embraced more individuals, known as the Antediluvians, of which all 13 clans can trace their origins back to one of 13 individuals. When the Antediluvians turned on their sires and killed them, he cursed them with Clan weaknesses. He then disappeared into myth, though it became a belief among some Vampires that he will return during an event called the Gehenna.
- As a note, within VTM, the Camarilla don't actually truly believe in his existence and are undecided on if he ever did exist in the first place. This makes the presence of Corpse Hand being held by the Ventrue Clan, a clan of the Camarilla in Vampire Sphere different from the source material of which the comic draws most of its ideas and concepts from.